Professor Adrian Harris
Adrian L Harris is the Cancer Research UK Professor of Medical Oncology at the University of Oxford and directs the Cancer Research UK Molecular Oncology Laboratories at the Weatherall Institute of Molecular Medicine (WIMM). He is a Consultant Medical Oncologist and a Professorial Fellow of St Hugh’s College Oxford. He is Chairman of the CRUK Oxford Cancer Centre and joint lead of the Cancer theme of the Comprehensive Biomedical Research Centre in Oxford. He is Editor-in-Chief of the British Journal of Cancer and on the Editorial Board of Cancer Cell. He is a Senior Investigator in the National Institute of Health Research and a Fellow of the Academy of Medical Sciences.
He is a ‘Highly Cited Researcher 2014’ ranking among the top 1% most cited for their subject field and year of publication—between 2002 and 2012 and included in Thompson Reuters ‘2014 World’s most Influential Scientific Minds.’ He is also listed in Boyack KW, et al. A list of highly influential biomedical researchers, 1996-2011. Eur J Clin Invest. 2013 43:1339-65. These are Top 400 world-wide cited investigators in all biomedical fields. He has published over 1000 papers and there are over 105,000 citations to them.
He has received a Platinum Merit Award from then National Health Service for the last 15 years, given to the 200 most outstanding consultants for all specialities.
He trained in Medicine and Biochemistry at Liverpool University, did a DPhil at Oxford University then trained at the Royal Marsden Hospital in Medical Oncology. He was appointed Professor of Clinical Oncology at Newcastle-upon-Tyne in 1982. Since 1988 he has been the Professor of Medical Oncology at Oxford University. He directs the Molecular Oncology Laboratories at the Weatherall Institute of Molecular Medicine. He has managed breast cancer patients for over 30 years.
His major laboratory interests involve the role of hypoxia in breast tumour biology, and tumour angiogenesis, the metabolic response to hypoxia, microRNAs induced by hypoxia and hypoxia-induced cell death. He has conducted many predictive and prognostic studies and early exploratory phase trials in new drug development and molecular pathology to translate laboratory findings to clinical relevance and development of new agents.
In the Department of Oncology over 20 Phase I and II trials are run and current trials include new drugs blocking angiogenesis, metabolism inhibitors, DNA repair, immunotherapy, inhibitors of signal transduction and their interactions with radiotherapy. Specific emphasis is on classification of tumours by functional imaging, molecular profiles, and pharmacodynamic endpoints to targeted therapies.