Each session aims to address a key problem in the breast cancer research field from both a clinical and research perspective through expert speakers, discussion and debate.
Professor Sir Mike Stratton
CHAIR – Professor Sir Mike Stratton
Dr James Flanagan – Epigenetic mechanisms for breast cancer risk
Professor Paul Pharoah – Genetics and epigenetics
Dr Alison Dunning – Breast cancer risk alleles, in seperate gene-regulatory elememnts across 6q25 regulate the ESR1, RMND1 and CCDC170 genes and alter breast tumour traits
CHAIR – Professor Jacqui Shaw
Professor Carlos Caldas – Genomic stratification of breast cancer: time to move into the clinic
Professor Gary Johnson – Chromatin Remodeling and Transcriptomic Changes Drive the Breast Cancer Adaptive Response to Targeted Kinase Inhibition
Dr Steffi Oesterreich – Sensitive detection of mono- and polyclonal ESR1 mutations in primary tumours, metastatic lesions and cell free DNA of breast cancer patients
CHAIR – Professor Clare Isacke
Professor Carsten Denkert – Tumour-infiltrating lymphocytes and tumour immunology – new biomarkers and therapeutic strategies
Dr Fernando Calvo – Disrupting coordinated cytoskeletal networks inactivates cancer-associated fibroblasts and deters breast cancer progression
Professor Adrian Harris
This session will explore how hypoxia regulates the response to antihormone therapy and drug resistance; in turn leading to new therapy approaches targeting chromatin response to hypoxia.
Professor Clare Isacke
Emma Young will be sharing her experiences and perspectives on living with secondary breast cancer. Emma was diagnosed with breast cancer in May 2014, and just five days after her initial diagnosis was told she had secondary tumours in her bones. Emma is 37 and a mother to three children – two girls and one boy. In 2015 Emma played a vital part in Breast Cancer Now’s campaign, ‘The Last One’, appearing on television and sharing her story in the national media to encourage the public to support breast cancer research.
CHAIR – Professor Adrian Hayday
Dr Guiseppe Curigliano – Immunotherapy for breast cancer – hope or hype
Professor Tony Ng – Lymphoid Tissue Inducer Cells Promote Lymph Node Metastasis in Human Breast Cancer
Dr Rebecca Marlow – Patient-derived xenograft models of breast cancer with human immune components
CHAIR – Professor Valerie Speirs
Dr Robert Clarke – Use of patient-derived tissues for advanced in vitro/in vivo models of breast cancer
Professor Christine Watson – Modelling breast cancer in 3D engineered collagen scaffolds
Dr Cigdem Selli – Long-term neoadjuvant endocrine treatment as a clincal model of breast cancer dormancy
CHAIR – Dr Chris Lord
Dr Thomas “Trey” Westbrook
Professor Andrew Tutt – The DNA damage response in breast cancer: Finding the scarred, stressed and lacking in focus
Dr Jo Morris – Synthetic lethality and viability: how does BRCA1 interact with 53BPI?
Dr Dennis Slamon
Abstract prizes will be awarded to the best oral and best poster presentation