Programme

Click on each session and speaker for further details

Each session aims to address a key problem in the breast cancer research field from both a clinical and research perspective through expert speakers, discussion and debate.

Day 1
22 Jul 2016
Day 2
23 Jul 2016
08:30 - 10:20

Registration opens in the Wolfson Foyer

Introduction

Professor Charles Coombes
Professor Charles Coombes

Plenary session – Signatures of Mutational Processes in Human Cancer

Professor Sir Mike Stratton

Professor Sir Mike Stratton
Professor Sir Mike Stratton
11:00 - 11:30

Coffee and tea break

Session 1: Genetics and epigenetics

CHAIR – Professor Sir Mike Stratton

 

 

Dr James Flanagan – Epigenetic mechanisms for breast cancer risk

 

 

Professor Paul Pharoah – Genetics and epigenetics

 

 

Dr Alison Dunning – Breast cancer risk alleles, in seperate gene-regulatory elememnts across 6q25 regulate the ESR1, RMND1 and CCDC170 genes and alter breast tumour traits

Professor Sir Mike Stratton
Professor Sir Mike Stratton
Dr James Flanagan
Dr James Flanagan
Abstract Speaker
Selected Abstract Presentation

Session 2: Coping with Tumour Evolution

CHAIR – Professor Jacqui Shaw

 

 

Professor Carlos Caldas – Genomic stratification of breast cancer: time to move into the clinic

 

 

Professor Gary Johnson – Chromatin Remodeling and Transcriptomic Changes Drive the Breast Cancer Adaptive Response to Targeted Kinase Inhibition

 

 

Dr Steffi Oesterreich – Sensitive detection of mono- and polyclonal ESR1 mutations in primary tumours, metastatic lesions and cell free DNA of breast cancer patients

Professor Jacqui Shaw
Professor Carlos Caldas
Professor Carlos Caldas
Professor Gary Johnson
Professor Gary Johnson
Abstract Speaker
Selected Abstract Presentation
14:45 - 15:15

Coffee and tea break

Session 3: Targeting the Tumour Microenvironment

CHAIR – Professor Clare Isacke

 

Professor Carsten Denkert – Tumour-infiltrating lymphocytes and tumour immunology – new biomarkers and therapeutic strategies

 

Dr Fernando Calvo – Disrupting coordinated cytoskeletal networks inactivates cancer-associated fibroblasts and deters breast cancer progression

Professor Clare Isacke
Professor Carsten Denkert
Professor Carsten Denkert

Plenary session – Interaction of hypoxia and metabolism in breast cancer

Professor Adrian Harris

Hypoxia is a key driver in stimulating genetic diversity and clonal evolution via gene amplification.

This session will explore how hypoxia regulates the response to antihormone therapy and drug resistance; in turn leading to new therapy approaches targeting chromatin response to hypoxia.

Professor Adrian Harris
Professor Adrian Harris

Poster Session and Drinks Reception

Submit an abstract for the opportunity to present your research and the chance to win a £500 prize.

18:30

Garden BBQ

08:40 - 09:10

Registration opens in the Wolfson Foyer

Patient Perspective

Emma Young will be sharing her experiences and perspectives on living with secondary breast cancer. Emma was diagnosed with breast cancer in May 2014, and just five days after her initial diagnosis was told she had secondary tumours in her bones. Emma is 37 and a mother to three children – two girls and one boy. In 2015 Emma played a vital part in Breast Cancer Now’s campaign, ‘The Last One’, appearing on television and sharing her story in the national media to encourage the public to support breast cancer research.

Emma Young

Session 4: Immunology

CHAIR – Professor Adrian Hayday

 

 

Dr Guiseppe Curigliano – Immunotherapy for breast cancer – hope or hype

 

 

Professor Tony Ng – Lymphoid Tissue Inducer Cells Promote Lymph Node Metastasis in Human Breast Cancer

 

 

Dr Rebecca Marlow – Patient-derived xenograft models of breast cancer with human immune components

Professor Adrian Hayday
Professor Adrian Hayday
Dr Giuseppe Curigliano
Professor Tony Ng
Abstract Speaker
Selected Abstract Presentation
11.10 - 11:40

Coffee and tea break

Session 5: Modelling breast cancer

CHAIR – Professor Valerie Speirs

 

 

Dr Robert Clarke – Use of patient-derived tissues for advanced in vitro/in vivo models of breast cancer

 

 

Professor Christine Watson – Modelling breast cancer in 3D engineered collagen scaffolds

This session offers insight into the different types of models used to study breast cancer in the laboratory, in particular PDX and 3D models and their applications in breast cancer research.)

 

 

Dr Cigdem Selli – Long-term neoadjuvant endocrine treatment as a clincal model of breast cancer dormancy

Professor Valerie Speirs
Professor Valerie Speirs
Dr Rob Clarke
Dr Rob Clarke
Abstract Speaker
Selected Abstract Presentation

Session 6: DNA Repair / Synthetic Lethality

CHAIR – Dr Chris Lord

 

 

Dr Thomas “Trey” Westbrook

 

 

Professor Andrew Tutt – The DNA damage response in breast cancer: Finding the scarred, stressed and lacking in focus

In this session we will discuss both pre-clinical and clinical approaches to identifying and assessing synthetic lethal effects that operate in breast cancer. Two stellar speakers will highlight some of the recent advances in the field. Trey Westbrook (MD Anderson) will discuss his recent work highlighting efforts to synthetically lethal target MYC dependency in breast cancer, whilst Andrew Tutt (ICR and KCL, London) will discuss his work on exploiting DNA repair synthetic lethal approaches in breast cancer.

 

 

Dr Jo Morris – Synthetic lethality and viability: how does BRCA1 interact with 53BPI?

Dr Chris Lord
Dr Chris Lord
Professor Trey Westbrook
Dr Thomas “Trey” Westbrook
Professor Andrew Tutt
Professor Andrew Tutt
Abstract Speaker
Selected Abstract Presentation

Plenary session and concluding remarks

Dr Dennis Slamon

Dr Dennis Slamon

Award Ceremony

Abstract prizes will be awarded to the best oral and best poster presentation

Baroness Delyth Morgan
Professor Charles Coombes
Professor Charles Coombes

Closing of conference

Professor Charles Coombes
Professor Charles Coombes